I hope you've already got Rick Mansfield's excellent blog bookmarked, but just in case, I want to mention that he's posted a hands-on review of the TNIV Reference Bible, and a follow-up that features his own mock-up for a wide-margin edition (which looks great). Unfortunately, it looks like the publishers are sticking with that oddball font choice -- otherwise, the design seems very attractive. It's a single column setting, which always warms my heart. If you haven't already, be sure to check it out.
J Mark Bertrand